Botanic Choice lemon balm liquid extract, 1 fl oz dropper

Botanic Choice lists the size as 1 oz and describes the extract as alcohol-free. The bottle photo prints 1 fl oz (30 mL). The suggested use is 1 mL, one or two times a day, in a small amount of water. Botanic Choice lemon balm liquid extract Botanic Choice lemon balm bottle photo

The supplement facts on that page set the serving at 1 mL (about 28 drops), with 30 servings in the bottle. Lemon balm extract (herb) 3:1 is 240 mg, and the herbal equivalent is 720 mg. Other ingredients are glycerin and purified water. Botanic Choice lemon balm liquid extract

A benefits line says to add it to water or juice, preferably at night. The page also describes the herb as historically used for calming. Both lines are the brand's wording. Botanic Choice lemon balm liquid extract

Kennedy, Scholey, and colleagues randomized 20 healthy young adults to single doses of 300 mg, 600 mg, and 900 mg of a standardized Melissa officinalis extract made by Pharmaton, or to placebo, with 7 days between doses. Calmness on the Bond-Lader scale rose at the earliest checks after the 300 mg dose. Alertness fell at every check after the 900 mg dose. Accuracy of attention improved after 600 mg, and some memory scores fell at particular doses and times. Kennedy et al. 2002 trial of lemon balm, mood, and attention

A second crossover gave 18 healthy adults 300 mg, 600 mg, and placebo on separate days, again with 7 days between them. During a 20-minute lab stress battery, 600 mg increased calmness ratings and reduced alertness. After 300 mg, people finished the math items faster, and accuracy did not drop. The authors said the stress result deserved another study. Kennedy et al. 2004 trial of lemon balm during a lab stress test

Cases and colleagues ran a 15-day open-label pilot of Cyracos, a different standardized Melissa extract, in 20 adults with mild-to-moderate anxiety and sleep problems. They reported an 18 percent reduction in anxiety manifestations, a 15 percent reduction in associated symptoms, and a 42 percent reduction in insomnia. Nineteen of the 20 people were counted as responding. There was no placebo group. The authors wrote that a placebo trial was still needed. Cases et al. 2011 open-label pilot of a Melissa officinalis extract

Auf'mkolk and colleagues tested freeze-dried extracts of Melissa officinalis and three other plants, plus some oxidized constituents, against the antibodies found in Graves' disease. In the samples they ran, the active extracts lowered those antibodies' ability to block TSH binding, and they did it in a dose-dependent way. The work was in lab assays, not in people taking this 1 mL glycerin extract. Auf'mkolk et al. 1985 laboratory study of plant extracts and Graves' immunoglobulin

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