Heivy liquid vitamin D3 drops, 100 mcg 4000 IU dropper

The front prints 2 fl oz (60 ml) and 60 servings next to the 100 mcg (4000 IU) line. The page calls the form cholecalciferol. The serving it names is 20 drops, equal to 1 ml, taken once a day with a meal, and it says shake well before use. Sixty servings of 1 ml match a 60 ml bottle. Heivy vitamin D3 drops pack shot Heivy liquid vitamin D3 drops product page

The two-pack photo is two of the same pineapple bottles. Heivy vitamin D3 drops two-pack photo

The back says adult use only, and do not use if pregnant or lactating. Heivy vitamin D3 drops back panel

The two-pack page lists Primary Supplement Type as Vitamin D2. The facts panel and the single-bottle page say cholecalciferol. Heivy vitamin D3 drops two-pack product page Heivy vitamin D3 drops supplement facts panel Heivy liquid vitamin D3 drops product page

The two-pack page says refrigerate after opening. The bottle back says store in a cool, dry place. Heivy vitamin D3 drops two-pack product page Heivy vitamin D3 drops back panel

ODS, in the consumer sheet updated November 8, 2022, lists 15 mcg (600 IU) for adults 19 to 70 and 20 mcg (800 IU) from age 71. The upper limit for adults 19 and older is 100 mcg (4,000 IU), counting food, beverages, and supplements. This bottle's serving is that 100 mcg (4,000 IU) limit. NIH ODS vitamin D fact sheet Heivy vitamin D3 drops supplement facts panel

The sheet says a health care provider might recommend more than that limit for a time to treat a vitamin D deficiency. NIH ODS vitamin D fact sheet

The sheet calls a blood level above 125 nmol/L (50 ng/mL) too high. It says blood levels of vitamin D above 150 ng/mL can cause nausea, confusion, and kidney stones, and that levels that high almost always come from supplements rather than sun. It also says vitamin D helps the body absorb calcium. NIH ODS vitamin D fact sheet

The sheet says a vitamin D supplement can interact with certain medicines. Orlistat can reduce vitamin D absorption. High-dose vitamin D might make cholesterol-lowering statins work less well. Steroids such as prednisone can lower vitamin D levels. Thiazide diuretics could raise blood calcium too high. NIH ODS vitamin D fact sheet

Tripkovic and colleagues pooled randomized trials that compared vitamin D3 with vitamin D2 head to head. D3 raised serum 25-hydroxyvitamin D more than D2, with P = 0.001. When they split the trials by schedule, the D3 advantage was there for a bolus dose (P = 0.0002) and was lost with daily supplementation. Tripkovic et al. 2012 meta-analysis comparing vitamin D2 and D3

The Heivy direction is a daily serving, which is the schedule where that D3 advantage disappeared. The page still names the form as cholecalciferol. Heivy liquid vitamin D3 drops product page Tripkovic et al. 2012 meta-analysis comparing vitamin D2 and D3

Dawson-Hughes and colleagues gave 50 healthy older adults one 50,000 IU dose of vitamin D3 with breakfast. At 12 hours, mean plasma vitamin D3 was 32 percent higher after meals that contained fat than after a fat-free meal. The 95 percent confidence interval was 11 percent to 52 percent. The monounsaturated-to-polyunsaturated ratio of that fat did not change absorption. The Heivy page says to take the drops with a meal. The trial dose was 50,000 IU, not 4000 IU. Dawson-Hughes et al. 2015 trial on dietary fat and vitamin D absorption Heivy liquid vitamin D3 drops product page Heivy vitamin D3 drops pack shot

The facts panel lists organic MCT oil and organic natural pineapple flavor as the other ingredients. Heivy vitamin D3 drops supplement facts panel

Demay and colleagues, for the Endocrine Society in 2024, suggested against empiric vitamin D above the current dietary reference intake for healthy adults younger than 75, when the goal is lowering disease risk and no 25-hydroxyvitamin D test has set the dose. They defined empiric use as intake above the reference intake, started without that test. Demay et al. 2024 Endocrine Society guideline on vitamin D

The same guideline says trial amounts were far apart, and many people using vitamin D were not required to stop, so it did not name one best empiric dose. It suggests empiric vitamin D for adults 75 and older. It suggests against routine 25-hydroxyvitamin D testing in the populations it considered. It does not replace the dietary reference intakes, and it does not cover people who already have a reason for vitamin D treatment or testing. Demay et al. 2024 Endocrine Society guideline on vitamin D

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